Page 32 - SDIR5 Abstract book 21 12 2021.

RADIOBIOLOGY

Can miRNA expression patterns predict radiotoxicity in patients with glioblastoma?

2,3
1
1,4
1,4
Aleksandar Stepanović , Nina Petrović , Tatjana Arsenijević , Marina Nikitović
1 Institute for Oncology and Radiology of Serbia, Department of Radiation Oncology, Pasterova 14 Street, 11000
Belgrade, Serbia
2 Institute for Oncology and Radiology of Serbia, Department of Experimental Oncology, Pasterova 14 Street, 11000
Belgrade, Serbia
3 Laboratory for Radiobiology and Molecular Genetics, Department of Health and Environment, "VINČA" Institute of
Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, Mike Petrovića Alasa 12-14
Street, 11001 Belgrade, Serbia
4 Faculty of Medicine, University of Belgrade, Dr Subotica 8 Street, 11000 Belgrade, Serbia

Background: Standard treatment of the glioblastoma patients is implemented with Stupp’s protocol since
2005, but 2-years survival of the patients are still at low percentage. Even with implementation of modern
radiotherapy techniques, acute radiotoxicity is still observed in these patients. Micro RNAs (miRNAs)
expression patterns are introduced in recent years as factors that might predict survival in patients with
glioblastoma, as well as cancer treatment related side effects. Material and methods: The data used in this
review were conducted from research papers in PUBMED/MEDLINE databases with a special focus on role
of miRNAs in cancer and with emphasis on brain tumors correlated to acute radiotoxicity. Results:
Inflammation due to oxidative stress via free radicals is one of the mechanisms of radiation injury of
irradiated cells and may correlate with toxicity. MiRNAs expression in prostate cancer patients may predict
acute radiotoxicity, while miRNAs expression levels that could predict radiation toxicity in glioblastoma are
still under investigation. However, it has been shown that miRNA levels like miR-16, miR 21, miR-19a and
miR-22 are increased after radiation in glioma, while levels of miR-107, miR-181a are decreased.
Conclusion: Recent studies have shown that miRNAs may have role as potent indicator of radiotoxicity in
cancer patients. To date, there is no available data about acute brain radiotoxicity and its correlation with
expression levels of mRNAs in patients with GB. There is a emerge need for further investigation on role of
radioresponsive miRNAs in glioblastoma patients with acute radiotoxicity.
Keywords: acute radiotoxicity, cancer, glioblastoma, miRNA

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