Page 176 - SRPSKO DRUŠTVO ISTRAŽIVAČA RAKA

Serbian Association for Cancer Research SDIRSACR

G0 and G2 phases. FK866 also promotes mitochondrial biogenesis in hypoxia and stimulates the expression of genes
related to NADH dehydrogenase, HIF-1α, and Nanog, especially at 0.5 nM concentration.
Conclusions: Collectively, these results show that the FK866 inhibitor influences the cell cycle, mitochondrial
biogenesis, and crosstalk with BMAT in multiple myeloma cells, with its effects varying based on oxygen availability.
This underscores FK866’s potential to regulate NAD+ metabolism and positions it as a therapeutic agent targeting
metabolic pathways in MM.

Acknowledgments and funding: This work is supported by the Ministry of Science, Technological Development and
Innovation of the Republic of Serbia [Contract # 451-03-136/2025-03/200015 from 04.02.2025 with the Institute for
Medical Research, University of Belgrade, National Institute of the Republic of Serbia] and bilateral project Serbia-
Germany (DAAD) 2023-2024, #337-00-27/2023-05/11.

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