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SDIRSACR                                                                                 Oncology Insights



        Conclusion
        Our study provides valuable insight into trends in tumor pathology in Serbian CRC patients and confirms the beneficial
        effects of the introduction of the national screening program.


        Acknowledgements – None.

        Declaration of conflicting interest - The author(s) declared no potential conflicts of interest with respect to the research,
        authorship, and/or publication of this article.

        Funding statement - This work was supported by the grant 451-03-47/2023-01/200110 of the Ministry of Education,
        Science and Technological Development of the Republic of Serbia.

        Ethics statement
        The authors declare that the procedures were followed according to the regulations established by the Clinical Research
        and Ethics Committee and to the Helsinki Declaration of the World Medical Association updated in October 2024. All
        patients signed an informed consent.

        Data availability
        The data that support the findings of this study are available from the corresponding author upon reasonable request.

        References

        1.  The Lancet. GLOBOCAN 2018: counting the toll of cancer. Lancet 2018; 392: 985. 20180920.

        2.  Høydahl Ø, Edna TH, Xanthoulis A, Lydersen S and Endreseth BH. Long-term trends in colorectal cancer: incidence,
            localization, and presentation. BMC Cancer 2020; 20: 1077. 20201110.

        3.  Vuik FE, Nieuwenburg SA, Bardou M, Lansdorp-Vogelaar I, Dinis-Ribeiro M, Bento MJ, et al. Increasing incidence of
            colorectal cancer in young adults in Europe over the last 25 years. Gut 2019; 68: 1820-1826. 20190516.

        4.  Siegel RL, Miller KD, Fuchs HE and Jemal A. Cancer statistics, 2022. CA Cancer J Clin 2022; 72: 7-33. 20220112.

        5.  Habr-Gama A, Perez RO, Nadalin W, Sabbaga J, Ribeiro U, Silva e Sousa AH, et al. Operative versus nonoperative
            treatment for stage 0 distal rectal cancer following chemoradiation therapy: long-term results. Ann Surg 2004; 240:
            711-717; discussion 717-718.
        6.  Roseweir AK, McMillan DC, Horgan PG and Edwards J. Colorectal cancer subtypes: Translation to routine clinical
            pathology. Cancer Treat Rev 2017; 57: 1-7. 20170504.

        7.  Nagtegaal ID. Current concepts of colorectal cancer resection pathology. Histopathology 2015; 66: 102-111.

        8.  Nagtegaal ID, Odze RD, Klimstra D, Paradis V, Rugge M, Schirmacher P, et al. The 2019 WHO classification of tumours
            of the digestive system. Histopathology 2020; 76: 182-188. 20191113.
        9.  Amin MB, Edge SB, American College of S and American Joint Committee on Cancer. ‡b Collaborative Staging Task F.
            AJCC cancer staging system - version 9 (2024). Version 9 ed. Chicago, IL: American College of Surgeons [etc.], 2024.

        10. Mandard AM, Dalibard F, Mandard JC, Marnay J, Henry-Amar M, Petiot JF, et al. Pathologic assessment of tumor
            regression after preoperative chemoradiotherapy of esophageal carcinoma. Clinicopathologic correlations. Cancer
            1994; 73: 2680-2686.

        11. Bray  F,  Ferlay  J,  Soerjomataram  I,  Siegel  RL,  Torre  LA  and  Jemal  A.  Global  cancer  statistics  2018:  GLOBOCAN
            estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018; 68: 394-
            424. 20180912.

        12. Sinicrope FA. Increasing Incidence of Early-Onset Colorectal Cancer. N Engl J Med 2022; 386: 1547-1558.

        13. Abancens M, Bustos V, Harvey H, McBryan J and Harvey BJ. Sexual Dimorphism in Colon Cancer. Front Oncol 2020;
            10: 607909. 20201209.


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