Page 54 - SDIR5 Abstract book 21 12 2021.
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POSTER PRESENTATIONS
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Genetic analysis of SMAD7 3′UTR in human colorectal cancer
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Jovana Rosic , Marko Miladinov , Sandra Dragicevic , Tamara Babic , Zoran Krivokapic 1,2,4 , Aleksandra
Nikolic 3
1 Faculty of Medicine, University of Belgrade, Serbia
2 Clinic for Digestive Surgery, University Clinical Center of Serbia, Serbia
3 Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Serbia
4 Serbian Academy of Sciences and Arts, Serbia
Background: SMAD7 is a pleiotropic regulator with an inhibitory role pivotal for the control of the TGF-β
pathway. Several SMAD7 variants have been associated with colorectal cancer (CRC) risk and proven to
disrupt the SMAD7-mediated regulation of the TGF-β cascade involved in malignant cell processes. This
study aimed to analyze SMAD7 3′UTR variants in CRC tumor tissue, considering their relevance for the
regulation of gene expression. Patients and Methods: Primary tumor tissue samples obtained from 50
colorectal cancer patients who underwent surgical resection without preoperative chemoradiotherapy
were used in this study. The 1126 nt long genomic region of SMAD7 3′UTR (48,920,135–48,921,260; Homo
sapiens GRCh38.p13 Primary Assembly) was analyzed by polymerase chain reaction (PCR) using two primer
sets followed by direct DNA sequencing. Results: Two single nucleotide polymorphisms (SNPs) were
detected in 5 CRC cases, rs16950113 (T>C) in 4 patients and rs1050799536 (G>A) in one patient.
Conclusion: Detected variants should be further functionally annotated since variation in potential miRNA-
binding sites in the 3′UTR of SMAD7 may modulate expression and increase susceptibility to CRC.
Furthermore, in silico analysis using the PolymiRTS Database 3.0 (available at
https://compbio.uthsc.edu/miRSNP/) predicted that the derived allele of rs16950113 disrupts conserved
and creates a new miRNA site, indicating its functional impact.
Keywords: Colorectal Cancer, SMAD7, SNP, 3'UTR
Acknowledgements. This work was supported by the strategic project of the Serbian Academy of Sciences
and Arts (grant agreement No 02-2019) Molecular basis of response to chemioradiotherapy in rectal cancer
- MOHERATEKA, F-69.
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