Page 59 - SDIR5 Abstract book 21 12 2021.

POSTER PRESENTATIONS

P19

Triple negative breast cancer and anoikis

1
Seda Yılmaz , Zekiye Altun 1
1 Seda Çumralı Yılmaz, Department of Basic Oncology, Institute of Oncology, Dokuz Eylul University, Izmir, Turkey,
2 Zekiye Altun, Department of Basic Oncology, Institute of Oncology, Dokuz Eylul University, Izmir, Turkey,

Background: Estrogen, progesterone and HER2 expression negative-triple negative breast cancer (TNBC)
with poor prognosis, constitutes 10-15% of all breast cancer cases. Chemotherapy is currently the only
systemic treatment option for TNBC. Anoikis is the induction of apoptosis in cells upon loss of connection
with the extracellular matrix (ECM) and neighboring cells. Anoikis can regulate the survival of ECM-
independent cells. Material and methods: In this review, TNBC and anoikis-related articles were evaluated.
Results: Changes in gene expressions of S100a7, MnSOD, TGF-β1, AMPK and Hypoxia/reoxygenation
signaling in metastatic cells growing independently of anchorage play a role in anoikis resistance through
nuclear factor NF-κB, ensures cell survival. In healthy cells, Snail and FAK expression are suppressed when
the cell-cell connection is disrupted. In metastatic cells, the expression of these proteins is increased by NF-
kB. In addition, the sensitivity to anoikis increases with inhibition of TDO2 expressed. The role of anoikis is
seen in metabolism related studies aimed at preventing proliferation and invasion in TNBC. The miRNA200
family, which is prominent in prognostic and diagnostic aspects for TNBC, has been shown to play a role in
anoikis regulation in TNBC and different cancer types. Resistance to anoikis develops as the highly
expressed nerve growth factor receptor suppresses pro-apoptotic genes in TNBC. Proteins or pathways
that can be biomarkers in determining poor prognosis and metastatic potential play a role in the
development of resistance to anoikis. Conclusion: The development of targeted therapy should be focused
on effective ways in the anoikis process in TNBC.
Keywords: TNBC, anoikis, metastasis

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