Page 55 - SDIR5 Abstract book 21 12 2021.
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POSTER PRESENTATIONS



               P15



                  The expression of MicroRNA-30a-3p and Estrogen Receptor β in Papillary Thyroid Cancer

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                         Lidija Todorović , Boban Stanojević , Bojana Kožik , Ana Božović , Vesna Mandušić 1
                1 “Vinča” Institute of Nuclear Sciences, National Institute of the Republic of Serbia, University of Belgrade, Belgrade,
                                                            Serbia

               Background:  A number of studies point to a significant role of microRNAs (miRNAs) in papillary thyroid
               cancer  (PTC),  where  specific  miRNA  expression  profiles  associate  with  distinct  clinical  and  biological
               phenotypes of the lesion. One of the microRNAs deregulated in PTC is miR-30a-3p. Evidence suggests that
               estrogen receptor β (ERβ), also found to be deregulated in PTCs, may directly regulate microRNA-30a-3p
               biogenesis  and  expression.  Considering  the  possibility  that  ERβ  might  influence  PTC  cell  behavior  via
               miRNAs, in particular, miR-30a-3p, we have investigated their expression and correlation in PTCs with
               different  clinico-pathological  characteristics.  Patients  and  Methods:  Quantitative  PCR  was  used  to
               determine the relative miR-30a-3p and ERβ expression levels in 37 pairs of PTCs and matched non-tumor
               thyroid tissues. Results: The expression levels of miR-30a and ERβ were significantly altered in tumors
               compared with non-tumor tissues. A negative correlation between miR-30 and ERβ was detected in tumors
               with  pT4  category  (P=0.038,  r  =  -  0.738)  and  capsular  invasion  (only  in  women)  (P=0.041.  r=  -0.552)
               compared to positive correlations (or trends) found in tumors with lower pT categories (pT1+pT2) (P=0.061,
               r=0.463) and tumors with no capsular invasion (P=0.019, r=0.618). Similar trend was found in tumors with
               classic papillary pattern in the group of women (P=0.09, r= - 0.432) while in women with histovariants other
               than classic there was a trend towards positive correlation (P=0.066, r=0.486). Conclusion: The results
               suggest that in some PTCs, ERβ might negatively regulate miR-30a expression, and the opposite roles they
               may play are associated with more aggressive tumor features.
               Keywords: ERbeta, MicroRNA-30a-3p, Papillary Thyroid Carcinoma
















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