Page 90 - SDIR5 Abstract book 21 12 2021.
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POSTER PRESENTATIONS



               P50



                Evaluation of the Potential Effect of Helichrysum arenarium Extract and Natural Compounds
                                  on Cancers Triggered by Obesity Mediated Inflammation

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                                    Asya Gülistan Orbayoğlu , Dilhan Evcimen , Mehmet Varol
                1 Department of Molecular Biology and Genetics, Faculty of Science, Kotekli Campus, Mugla Sitki Kocman University,
                                                        Mugla, Turkey

               Background: The Helichrysum spp. is represented by 27 taxa, 15 of which are endemic, in the flora of Turkey
               and is widely observed in Anatolia. Helichrysum arenarium (L.) Moench from the Helichrysum spp., is a
               perennial  plant  defined  as  "Sandy  Everlasting”.  In  Anatolia,  it  is  widely  used  for  its  diuretic,  anti-
               inflammatory and detoxifying properties, and is also thought to be effective in the treatment of cystitis,
               arthritis, rheumatism, gastric secretion stimulation and gallbladder disorders. Material and methods: In this
               study, the medicinal use of Helichrysum arenarium was explored by literature review. Results: Helichrysum
               arenarium  is  reported  to  have  anti-inflammatory,  anti-microbial,  anti-thrombotic,  anti-allergenic,  lipid-
               reducing, anti-stress, anti-hyperglycemia, vasodilator, detoxification and immune-stimulating effects. It has
               been shown that there are rich groups of phenolic compounds including flavonoids, chalcones, phenolic
               acids, phthalides, coumarins and pyrones from the extracts obtained from the flowers, and the presence
               of other compounds such as polyphenols, sterols and glycosides of aromatic compounds. The intracellular
               signaling mechanism is activated as a result of the anti-inflammatory effect mediated by the inhibition of
               c-Jun NH2-terminal kinases (JNK2) and p38 activities, especially by reducing the expression of C Reactive
               Protein (CRP), and also by suppressing the mitogen-activated protein kinase (MAPK) pathway. Moreover,
               methanol extract from Helichrysum arenarium flowers has been shown to inhibit tumor necrosis factor-α
               (TNF-α)-induced cytotoxicity in L929 cells. Other studies report that Helichrysum arenarium extracts might
               reduce blood lipid levels and suppress obesity. Conclusions: Helichrysum arenarium extracts and its natural
               compounds may be effective on some cancer subtypes triggered by obesity-induced inflammation.
               Keywords: anti-cancer therapy, Helichrysum arenarium, obesity.














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