Page 80 - SDIR5 Abstract book 21 12 2021.

POSTER PRESENTATIONS

P40

Evaluation of the Potential Effects of Cimcifuga racemosa Extract and Natural Compounds on
Different Cancers

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Dilhan Evcimen , Asya Gülistan Orbayoğlu , Mehmet Varol
1 Department of Molecular Biology and Genetics, Faculty of Science, Kotekli Campus, Mugla Sitki Kocman University,
Mugla, Turkey

Background: Conventionally, different approaches are used for the treatment of different cancer types,
especially chemotherapy, radiotherapy, biological therapy, immunotherapy and surgical methods.
However, observing the negative effects of these treatment methods increases the importance of new
generation drug development strategies. Natural compounds have been reported to be effective in the
prevention and treatment of various cancer subtypes Drugs designed by isolating the secondary
metabolites of plants are of great importance and 25% of the drugs used in modern medicine are natural
compounds. The Cimcifuga species grown in Far East Asian countries has been used in the treatment of
gynecologic disorders and menopausal symptoms and has been reported to have potential in anti-cancer
therapy. Material and methods: In this study, a literature review of studies exploring the medicinal use of
Cimcifuga racemosa is presented. Results: Cimcifuga racemosa extract have been reporte to inhibit the
proliferation of estrogen receptor-positive and negative human breast carcinoma cell lines by induction of
apoptosis. Its use has also been explored for the management of postmenopausal symptoms in breast
cancer survivors. Studies using prostate cancer cells have reported that by inhibiting prostate specific
antigen (PSA), the growth of cancer cells is blocked thus exhibiting an antiproliferative effect. Additionally,
Cimcifuga racemosa extracr has been reported to be able to prevent benign prostatic hyperplasia through
its 5-reductase inhibitors. Conclusions: Cimcifuga racemosa plant extract has the potential to be used in
cancer treatment but further studies evaluating its activity in vivo are necessary.
Keywords: anti-cancer therapy, Cimcifuga racemosa, natural products.

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